Based on the medical history of each individual as summarized in the passport, follow-up recommendations are included.
The recommendations are based on guidelines developed as part of the international EU funded project PanCareSurFup in collaboration with the International Guidelines Harmonization group. Each guideline is defined after extensive literature review and discussion among experts and identifies:
- who is at risk of possible late effects such as infertility, thyroid or other endocrinal dysfunctions, cardiac, renal or other problems;
- what examinations are suggested to diagnose the condition in useful time;
- when and how often such examinations should be performed;
- what to do if an anomaly is observed.
Currently, the passport includes guidelines for screening on secondary breast cancer, male and female gonadal insufficiency, cardiomyopathy.